CD4 and HIV infectious disease: Among elite controllers, HIV-specific cytotoxic CD4 T cell levels correlate with viral suppression.26, 27, 28 Due to CD4 T cell dysregulation in most individuals with HIV infection and the failure to restore antigen-specific memory CD4 T cells even after years of virus-suppressive antiretroviral therapy, it is particularly important to provide a therapeutic reconstitution of antigen-specific CD4 T cells as a means for re-establishing immunity against HIV.