The difference in STK11 gene expression was analyzed between these 5 null mutations and control groups A and B. The STK11 gene expression in colonic polyps of patients with null STK11 mutation (8.0 ± 2.9) was significantly decreased compared with control A (16.1 ± 2.2, P = 0.0005) and control B (14.7 ± 2.8, P = 0.004). Here, STK11 is linked to polyp of colon.