However, aged (52-week old) mice carrying the myeloid cell-specific knockout of Atg5 (lysozyme M-Cre+×Atg5f/f) demonstrated lupus-like symptoms, such as increased serum anti-dsDNA antibody, proteinuria levels, and kidney IC deposition, due to the deficiency of LC3-associated phagocytosis, which can promote the clearance of dying cells [27]. Here, LYZ is linked to systemic lupus erythematosus.