In the previous study, we have endeavored to investigate the relationship between HO-1 and NAFLD and demonstrated that the induction of HO-1 could eliminate steatohepatitis and hepatic fibrosis in the progression of NAFLD [11, 12], thus substantiating a significant role of HO-1 against heme-mediated steatohepatitis-related liver fibrosis. This evidence concerns the gene HMOX1 and metabolic dysfunction-associated steatotic liver disease.