Neurofibromatosis type 1 (NF-1), the incidence of which is 0.33%, is more common than neurofibromatosis type 2 (NF-2); NF-1 are frequently associated with musculoskeletal system defect, especially deformity; the incidence is 10%-64% [26]. This evidence concerns the gene NF1 and neurofibromatosis.