Patients were then accordingly reclassed into two groups with respect to the specific cut-off value; the critical values of TPO-Ab, TG-Ab, TG, and Fb related to the incidence of radiation-induced hypothyroidism were 7.40 IU/mL (normal value: 0-34 IU/mL), 57.40 IU/mL (normal value: 0-115 IU/mL), 16.65 ng/mL (normal value: 1.40-78 ng/mL), and 3.50 g/L (normal value: 2-4 g/L), respectively. The gene discussed is TPO; the disease is hypothyroidism.