Genetic markers of ccRCC include biallelic inactivation of Von Hippel-Lindau (VHL) tumor suppressor genes; negative regulators of hypoxia-inducible factor (HIF) protein; copy number changes of chromosome 3p, 5q, and 14q genes; and chromatin-modifying enzyme high mutation frequencies, such as protein polybromo-1 (PBRM1), SET domain containing 2 (SETD2), and BRCA1-associated protein-1 (BAP1) [6]. This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.