Since incorporating the p16INK4A immunohistochemistry and histopathologic diagnosis examination improves diagnosis of the cervical intraepithelial neoplasia (CIN), p16INK4A immunohistochemistry was assessed as the gold standard for defining the efficiency of cervical cancer screening methods (12). The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.