CCL3 and allergic rhinitis: CCL3 concentrations were significantly associated with NMH (p = 0.003 by Mann-Whitney U-test) and correlated with polysensitization (two or more positive skin prick tests per patient; r = 0.325, p = 0.046) and seasonal allergic rhinitis (r = 0.482, p = 0.002; Table 4). The observed correlation between NMH and seasonal allergic rhinitis might be explained by the fact that although SAR has a temporal clinical picture, a subclinical inflammation is presented at cellular levels all years and becomes active when allergens take direct contact with local mast cells.