STAT-1 knockout mice present with leukopenia, thrombocytopenia, elevated levels of serum hepatic alanine aminotransferase, and proinflammatory cytokines.75 CCHFV RNA is widespread in tissues of STAT-1−/− and IFNAR−/− mouse models.75,76 Additionally, a humanized mouse model was prepared by injecting NSG-SGM3 mice with CD34+ human stem cells.78 The humanized model displayed different disease patterns when inoculated with CCHF strain from Oman and Turkey. The gene discussed is STAT1; the disease is Decreased total leukocyte count.