While, calculating the allelic distribution Del allele ( SOD1 50bp Ins/ Del) was found to be more prevalent in the thalassemia patients with the frequency of 11.7% and 4% in cases and controls, respectively, and also statistically significant (OR=3.1955, 95% CI: 1.779-5.738, P= 0.0001). This evidence concerns the gene SOD1 and thalassemia.