Jurkat and Molt-4 cells have active PI3K/AKT/mTOR signaling due to mutations in PTEN compared to HPB-ALL cells with no active PI3K/AKT/mTOR .This is consistent with a recent study, which demonstrated that AKT inhibitors induced apoptosis in PTEN null cell lines with AKT activation28. This evidence concerns the gene MTOR and acute lymphoblastic leukemia.