Lewis et al. addressed that in NOTCH1-dependent T-ALL cell lines, inhibition of gamma secretase associated with decreased formation of intracellular domain of NOTCH1, reduced the activity of NOTCH1 signaling, and diminished cell viability22, but Yoon and his team found that some of T-ALL cells with activated Notch1 did not respond to GSI23 . Here, NOTCH1 is linked to acute lymphoblastic leukemia.