Although there are many studies suggesting that lower PON-1 and ARE activities are associated with the extent of CAD in patients with stable atherosclerotic cardiovascular diseases,19-22 the number of the studies investigating the association between PON-1 and ARE activities, together with the genetic polymorphism of PON-1, and SS1 in patients with acute STEMI is scant.23, 24. The gene discussed is PON1; the disease is coronary artery disorder.