A few studies have assessed the relationship between the prothrombin G20210A variant and the severity of CAD. 7, 19, 34  A pooled analysis demonstrated a higher prevalence of the GA genotype among patients with no or single-vessel disease than in those with multi-vessel disease (4.4% vs. 2.2%; relative risk: 2.0, 95% CI: 1.2–3.1).   3 4 In a case-control study, Russo et al.19 failed to show any relationship between the G20210A genetic variant and the severity of CAD in 660 consecutive patients referred for cardiovascular surgery. This evidence concerns the gene F2 and coronary artery disorder.