F2 and coronary artery disorder: Prior evidence for the association between the prothrombin G20210A polymorphism and CAD is conflicting.3, 21-24  In some studies, being a carrier of the mutation was linked to a higher risk for myocardial infarction.5, 25-27  Segev et al.   2 8 showed that among young patients with myocardial infarction and a few traditional risk factors, the prevalence of the prothrombin gene G20210A variant was significantly increased.