The lack of HOXA-related gene expression in those three YAP1–KMT2A fusion-positive sarcomas argues against a simple YAP1–KMT2A fusion that preserves these domains, but rather a complex YAP1–KMT2A–YAP1 fusion that retains the CxxC-binding domain but lacks the RD2 domain. The gene discussed is YAP1; the disease is sarcoma.