In fact, a review of all previously published YAP1–KMT2A fusion-positive sarcomas with reported breakpoints confirmed our observations, with KMT2A exons 5–6 (or exons 4–6) present in all predicted full-length transcripts and shared between sets of reciprocals (Table 1; patients #17–29), except in patient case #19; this lone exception demonstrated an out-of-frame 5′ KMT2A transcript lacking exon 6, similar to a low-level splice variant seen in the index case absent of KMT2A exon 6. Here, KMT2A is linked to sarcoma.