CD8A and neoplasm: It is estimated that more than 50% of patients with solid tumours receive radiotherapy (RT), which has an advantage over chemotherapy in that it limits systemic toxicity.85 In combination with immune checkpoint inhibitors, RT normalizes the tumour vascular system, enhances the expression of leukocyte adhesion molecules on endothelial cells, and results in secretion of CD8+ T-attracting chemokines.