In mice, VISTA is highly expressed on tumour-infiltrating leukocytes, while blockade enhances antitumour immunity in multiple tumour models.54 VISTA is mainly expressed on myeloid APCs and T cells, especially on Tregs.55 VISTA helps created an immunosuppressed tumour microenvironment by enhancing Treg maturation and inhibiting T cell activation. This evidence concerns the gene VSIR and neoplasm.