To this end, we depleted hnRNP H/F in the chemo- and radio-resistant GBM cell line LN18 and either analyzed DNA damage repair by monitoring H2AX phosphorylation or measured the cell survival fraction using clonogenic assays, after treatment with IR (Fig. 5d, e and Supplementary 10a–c) or TMZ (Supplementary 10d, e). Here, H2AX is linked to glioblastoma.