Consistent with the observation that RG4 structuration reduced hnRNP H/F RNA-binding (Fig. 1), we observed that the cPDS- (or PDS- (Supplementary Fig. 5a)) induced stabilization of RG4s resulted in the dissociation of hnRNP H/F from translating ribosomes in U251 (Fig. 2c, d, Supplementary Fig. 5a) and U87 (Supplementary Fig. 5b) GBM cells. Here, UNC119 is linked to glioblastoma.