Moreover, hnRNP H/F inhibition not only induced but also enhanced chemo- and radio-therapy-induced DNA damage correlated with reduced cell survival (Fig. 5, Supplementary Fig. 10), indicating that targeting the RG4-dependent and hnRNP H/F-sensitive regulatory mechanism sensitizes cancer cells to treatments currently used to treat GBM patients (Fig. 7). This evidence concerns the gene HNRNPH2 and glioblastoma.