NFKB1 and cardiac hypertrophy: Additional support for the role that inflammation has in frailty development comes from the Nfκb1−/− mice, in which the deficiency of nuclear factor kappa B (NF-κB) p105/p50 subunits results in chronic low grade inflammation and accelerated aging, and includes phenotypes closely related to frailty such as sarcopenia, body weight loss, and cardiac hypertrophy [97].