Indeed, in a model of adoptive cell transfer, we previously reported that hetIL-15 treatment led to enrichment, in an antigen-dependent manner, of Pmel-1 cells in B16 tumor sites expressing gp100.47 Additionally, we observed a reduction in the frequency of splenic XCR1+CD103+IRF8+ cDC1 in hetIL-15 treated animals while their frequency significantly increased in tumors. This evidence concerns the gene IRF8 and neoplasm.