TNF and rheumatoid arthritis: In rheumatoid arthritis (RA), the Dose REduction Strategy of Subcutaneous TNF inhibitors (DRESS) study concluded that disease activity guided dose reduction of anti-TNF is non-inferior and cost-effective, compared with maintaining regular dosing.21 22 However, extrapolation of these results to CD is questionable, since RA patients generally use different concomitant medication, suffer from different comorbidities and anti-TNF shows different pharmacodynamic characteristics in RA patients.23 24 In CD, adalimumab dose reduction is uncommon in daily practice.