Future studies are required to figure out the mechanisms involved in microbiota-mediated protection against invasive candidiasis, such as the location and function of Th17 cells, the pathway by which intestinal microbiota communicates with IL-17A and other factors (IFN-γ, IL-12, IL-22), the interaction between these cytokines, and the verification of specific species working during invasive candidiasis. The gene discussed is IL22; the disease is Candidiasis, Invasive.