VEGFA and early-onset autosomal dominant Alzheimer disease: Transplantation of the BMMSCs can promote angiogenesis in brain tissue as proved by (a) the fold change of expression marker such as VEGF; (b) interaction between VEGF and Aβ protein in experimental animal study; and (c) therapeutic effects of the VEGF in the murine model of Alzheimer’s disease [33–35].