IFNG and heart failure: After the occurrence of NPE, the ratio imbalance of receptors alpha and beta in lung tissue occurs under the excitement of sympathetic nervous, inducing the increase of the vascular permeability, as a result, inflammatory mediators such as IL-10, IL-13, IFN-γ will cause the increase of alveolar exudation, which further aggravates pulmonary edema and heart failure [48, 49].