Although we could not obtain tumor samples from lung metastasis because of multiple patterns and the difficulty of biopsy from a metastasis site, 100% consistency with HRAS alterations during the clinical course, specifically overexpressed HRASQ61R, and activation of downstream effectors confirmed at the single tumor cell level strongly indicated a RASophathy, and we hypothesized that HRAS-targeting strategies could be a potential palliative adjuvant therapy for this patient. This evidence concerns the gene HRAS and neoplasm.