Second, HRAS mutations are one of the major driver alterations in MIUBCs (5.1–20%) [75, 76], and there is a consistency in the type of HRAS mutations among different tumor samples obtained from the same patients with MIUBC [45], suggesting that the majority of recurrences in MIUBC are clonally related [46]. The gene discussed is HRAS; the disease is neoplasm.