The tumor cells in cluster B showed similar characteristics to those of tipifarnib-resistant tumor cells, including downregulation of the RAS and MAPK signaling pathways (Additional file 2: Figure S5C) and upregulation of IGFBP7, MDK, and B2M mRNA (Additional file 2: Figure S5D, E). The gene discussed is IGFBP7; the disease is neoplasm.