First, collagen alpha-1(XIV) chain (COL14A1)-expressing matrix cancer-associated fibroblasts (CAFs) (COL14A1 MatrixCAFs) [53] and actin alpha 2, smooth muscle (ACTA2)-expressing cancer-associated myofibroblasts (MyoCAFs) [54, 55] were identified within the fibroblast cluster in vehicle- and tipifarnib-treated PDX (Fig. 4c; Additional file 2: Figure S7). The gene discussed is ACTA2; the disease is cancer.