TF and Alzheimer disease: The link between disrupted intracellular Ca2+ signaling and iron-dyshomeostasis mediated neurodegeneration was not well established until recently when it was reported that abnormal Camkk2 in a triple-transgenic mouse model of AD (3xTg-AD) is associated with altered TF phosphorylation and TF-associated protein complexes in different regions of the brain [9].