Multiple signaling pathways associated with neurodegenerative diseases regulate CAMKK2 function either through intracellular Ca2+ release or through glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase 5 (CDK5)/ cyclic AMP (cAMP)-activated protein kinase A (PKA)-mediated control of CAMKK2 activity. The gene discussed is CDK5; the disease is neurodegenerative disease.