Multivariate analysis showed age (OS; p <  0.001, RFS; p <  0.001), tumor stage (OS; overall p <  0.001, RFS; overall p <  0.001), and nuclear FAM83H expression (OS; p = 0.005, RFS; p = 0.005) to be independent prognostic indicators of gallbladder carcinoma patients (Table 3). The gene discussed is SACK1H; the disease is gallbladder carcinoma.