In a search of the GEPIA database (Accessed 2 March 2020) [14], the mRNA expression of ZNF16 was elevated in breast cancer, cholangiocarcinoma, esophageal carcinoma, colon adenocarcinoma, head and neck squamous cell carcinoma, prostatic cancer and lung carcinoma compared with their normal counterpart tissues. This evidence concerns the gene ZNF16 and head and neck squamous cell carcinoma.