Our results showed that LPS-induced lung injury experienced pulmonary edema, lung tissue deconstruction, high level pulmonary expressions of TF and PAI-1, large amount of secretions of TF, PAI-1, TAT and decreased APC production in air space, and a high content of pulmonary fiber (high collagen III), all which indicated alveolar hypercoagulaiton and fibrinolysis inhibition. This evidence concerns the gene SERPINE1 and pulmonary edema.