Our previous studies confirmed NF-κB p65 also participated in regulation of LPS-induced hyperexpressions of procoagulant factor TF and fibrinolysis inhibitor PAI-1 in alveolar epithelial cell type ‖, demonstrating it was associated with alveolar hypercoagulation and fibrinolysis inhibition in ARDS. Here, NFKB1 is linked to acute respiratory distress syndrome.