SERPINE1 and acute respiratory distress syndrome: Our data showed that the changes of TF, PAI-1, and of some other procoagulant factors and fibrinolytic inhibitors in BALF, as well as of lung injuries and pulmonary edema did not reach the baseline in SN50- treated mice, which implies that SN 50 partially attenuated but not abrogated LPS-induced ARDS.