On the other hand, Friesenhengst et al. evaluated CYP19A1 expression in tumors of women with breast cancer, and the results showed a significant association between high CYP19A1 gene expression and estrogen receptor expression, menopausal status, metastasis-free survival, overall survival, disease-free survival and local and distant recurrence [11]. This evidence concerns the gene CYP19A1 and breast cancer.