TNF and atrial fibrillation: There are many evidences highlight that PB serves as a target for Nrf2/HO-1 Axis, reduces autonomic dysfunction and susceptibility to atrial fibrillation via deactivating NF-κB/TNF-α pathway, inhibits the proliferation and migration but promotes the apoptosis through inhibiting N-cadherin and GABAB receptor (Ye et al. 2019; Gao et al. 2019; Habtemariam 2019).