The results indicated that the level of Lp-PLA2 (OR = 1.049, CI = 1.034–1.064, P < 0.001), male sex (OR = 2.192, CI = 1.161–4.140, P = 0.016) and hypertension (OR = 1.965, CI = 1.034–3.736, P = 0.039) were risk factors for CSF. Here, PLA2G7 is linked to Hypertension.