Next, because of the functional importance of LINC00094 for ESCC, we focused on this ce‐lncRNAs to validate the motif analysis results, which predicted the binding of TCF3 and KLF5 to SEs (E1, E2, and E3) of LINC00094 (Fig. 8B). This evidence concerns the gene KLF5 and esophageal squamous cell carcinoma.