Cytoplasmic FOXD1‐AS1 sponges miR‐466 to increase PIK3CA expression, so as to activate the PI3K/AKT/mTOR signaling pathway and induce 4E‐BP1 phosphorylation, therefore leading to enhanced interaction of eIF4E with eIF4G, and resulting in boosted protein levels of FOXD1, which finally facilitate GC cell growth, metastasis, and chemoresistance. This evidence concerns the gene PIK3CA and gastric cancer.