The genes targeted were selected based on their upregulation in leukemic granulocyte-monocyte progenitor (GMP; Lin−Sca-1−c-Kit+CD34+FcγRII/III+) cells, enriched for LSCs in the MLL-AF9-driven murine leukemia model, relative to normal GMPs, according to global gene expression data (Table S1; Krivtsov et al., 2006; Wang et al., 2010). The gene discussed is MLLT3; the disease is leukemia.