RUNX1T1 and acute myeloid leukemia: Experiments depleting RUNX1-ETO in established AML cells have shown that it is required to maintain leukemic growth (Ptasinska et al., 2012) but have also demonstrated that RUNX1-ETO-regulated gene expression is complex, with multiple genes being up- and downregulated after knockdown (Ptasinska et al., 2014, Ptasinska et al., 2019), indicating that the entire transcriptional network of such cells is rewired in the presence of the fusion protein.