This hypothesis is supported by data from established t(8;21) AML cells that show that high CDK6 and CCND1/2 expression levels depend on the AP-1 transcription factor family, which mediates MAPK signaling and whose expression, in turn, depends on the presence of RUNX1-ETO (Martinez-Soria et al., 2019). The gene discussed is RUNX1; the disease is acute myeloid leukemia.