To further investigate the impact of acetylated Atg8a on the activation of autophagy, we focused on the deacetylase Sir2, a homolog of mammalian Sirtuin-1, that has been shown to play a role in lipid metabolism and insulin resistance (Banerjee et al., 2012, Palu and Thummel, 2016, Reis et al., 2010). This evidence concerns the gene SIRT1 and Insulin resistance.