IL17A and ankylosing spondylitis: Secukinumab (SEC) and Ixekizumab (IXE), both monoclonal IgG4 antibodies directed against the IL-17A, as well as brodalumab (BRO), a monoclonal antibody directed its receptor, have been successfully used for treating various autoimmune mediated disorders such as chronic plaque psoriasis (SEC, IXE, BRO), psoriatic arthritis (SEC), and ankylosing spondylitis (SEC) [8–12].