Here, we established and characterized a novel lymphoma cell line, FL‐SJC, that held chromosomal abnormalities of t(8;22)(q24;q11), t(14;18)(q32;q21), del2q and del3, as well as gene mutations of KMT2D/MLL2 and CREBBP. This cell line could provide a useful tool for studies on the malignant nature of FL. This evidence concerns the gene KMT2D and lymphoma.