EZH2 mutation which was associated with good prognosis, according to the newest risk prognostication developed in FL, the M7‐FLIPI,23 was not found in FL‐SJC, while CREBBP (a histone modification enzyme) mutation, which was associated with poor prognosis,23 was found in FL‐SJC MLL2, also known as KMT2D or ALR, is another histone modification enzyme, gene mutations of which are mainly found in lymphomas (especially DLBCL and FL from indolent to aggressive) and myeloma.34 This evidence concerns the gene CREBBP and plasma cell myeloma.