There was a decrease in the lymph node metastasis‐related trend of CD4+ T‐cell counts (F = 3.537, P = .004, Figure 2F), but an increased lymph node metastasis‐related trend of CD8+ HLA‐DR/ CD8+ T‐cell percentages (F = 4.247, P = .001, Figure 2G) and CD8+ CD38+/CD8+ T cells (F = 10.984, P < .001, Figure 2H). This evidence concerns the gene CD8A and metastatic malignant neoplasm in the lymph nodes.