In this study, we demonstrated that decreased levels of NK cells, CD8+ T cells, naïve CD4+/CD4+ T cells, and elevated percentages of the following T cells were associated with cancer incidence: memory CD4+/CD4+, CD8+ HLA‐DR+/CD8+, CD8+ CD38+/CD8+, and CD4+/CD8+. Here, CD4 is linked to cancer.