Finally, in a previous study of 268 patients and an age‐ and gender‐matched control sample of 557 healthy probands, a negative influence of the higher activity COMT 158Val/Val genotype on antidepressant treatment response was identified during the first 6 weeks of pharmacological treatment in MDD (Baune et al., 2008). The gene discussed is COMT; the disease is major depressive disorder.