The current findings extended previous observations about the effect of AMTA1 on NPC development; moreover, we also found that the change of MTA1 expression reversed the functional effect of miR-30e-5p on the metastasis of NC cells, suggesting that MTA1 is also a functional downstream mediator of miR-30e-5p in NPC cells. Here, MTA1 is linked to nevus comedonicus syndrome.