NOTCH1 and tongue cancer: For instance, one study by Rice et al. [11] showed that knockout of NOTCH1 could suppress the tumorigenesis effect of prostate cancer cells in rats, and could also down-regulate the metastatic ability of prostate cancer and enhance the sensitivity of the cancer to drugs, and one study by Gan et al. [12], confirmed that NOTCH1 in high level would accelerate the malignant growth and epithelial–mesenchymal transition (EMT) of tongue cancer and suppress their apoptosis.