Furthermore, one study by Li et al. [13] revealed that NOTCH1 prevented DNA damage and cell death through cascade reaction among ATM, CHK2 and p53, and one study by Fender et al. [14] revealed that NOTCH1 pathway promoted the EMT of colon cancer cells by regulating CD44, Slug, and Smad. This evidence concerns the gene NOTCH1 and colonic neoplasm.