CASP3 and gastric adenocarcinoma: Nar induces apoptosis in HeLa and HepG2 cells through activation of caspase-3, increased Bax/Bcl-2 ratio, and up-regulation of miR-19b expression [19–21,23,62,63]; in cervical cancer SiHa cells via death receptor and mitochondrial pathways [64]; and in gastric adenocarcinoma AGS cells via autophagic cell death through down-regulation of the PI3K/Akt/mTOR pathway, up-regulation of p21, activation of Beclin 1 and LC3B, and phosphorylation MAPK [65].