In this study, it is observed that the risk factor of developing CRC is noticed in G/C, C/T heterozygote and GC+GG, CT+TT (heterozygote+ mutant) in RAD51 (rs1801320) and XRCC2 (rs3218536) respectively but no significance is found in case of G/G and T/T mutant. This evidence concerns the gene XRCC2 and colorectal carcinoma.