LIPE and obesity due to melanocortin 4 receptor deficiency: The lipolytic action of the extract was mainly mediated by phosphorylation of hormone-sensitive lipase (the key enzyme in the mobilization of fatty acids in adipocytes) and its activity is regulated post-transcriptionally by reversible phosphorylation by protein kinase A and this might aid in development of therapeutic strategy in preventing obesity (Holm, 2003).