AFP and neoplasm: Addition of CIN increases detection sensitivity to 52.9% (Figure 4A, tumor size less than 3 cm), 85.7% (Figure 4B, tumor size between 3 and 5 cm), and 88.5% (4C, tumor size greater than 5 cm), which is higher than for AFP alone (Fisher test, P = .04, <0.01, and < 0.01, respectively).