In type 2 DM (T2DM), elevated insulin levels result in increased bioavailability of insulin‐like growth factor‐1 (IGF‐1) by reducing hepatic production of IGF‐binding proteins (IGFBPs) and PC cells highly express receptors of high‐affinity insulin and IGF‐1.26, 27. The gene discussed is INS; the disease is type 2 diabetes mellitus.