IL6 and acromegaly: Differences in AT mass might also explain the relatively higher circulating IL-6 levels in patients with GHD and controlled acromegaly (who are characterized by an increased AT mass) compared to patients with active acromegaly (who are characterized by a decreased AT mass) [50, 91, 162].Those patients are both characterized by an increased and pro-inflammatory transformed VAT mass, which is an important source of pro-inflammatory IL-6 [23, 84].