Finally, we successfully verified the FVIIa-dependent Cav1 phosphorylation (Fig. 8a) and the importance of Cav1 (Fig. 8b) and ITGβ1 (Fig. 8c) on the anti-apoptotic signaling downstream of TF in MDA-MB-231 breast cancer cells. The gene discussed is ITGB1; the disease is breast cancer.