CAV1 and Familial prostate cancer: However, the notion that secretable forms of CAV1 may be important in the context of cancer arose when Thompson and collaborators showed that androgen-insensitive prostate cancer cells secrete CAV1 and, most importantly, that elevated levels of serum CAV1 were detectable in samples from patients with advanced prostate cancer compared to the levels detected in the serum of healthy subjects [162].