MMP9 and hepatocellular carcinoma: Interestingly, the authors showed that the incubation of non-motile HCC cell lines with exosomes derived from motile HCC cell lines leads to an increase in the migration and invasion of these cells and that this may be due to the observed activation of PI3K/Akt and MAPK signaling pathways, as well as the increased secretion of the metalloproteinases MMP-2 and MMP-9 by recipient cells [60].