These results led the authors to propose a two compartment model of tumor metabolism, known as the “reverse Warburg effect” which proposes that a glycolytic, CAV1-deficient tumor stroma may transfer catabolites, such as ketones, l-lactate, fatty acids, and amino acids, to anabolic tumor cells and thus stimulate mitochondrial metabolism in cancer cells [179]. Here, CAV1 is linked to neoplasm.