Higher sclerostin levels were observed in patients with a history of smoking (59.08 vs 45.93 pmol/l; median, p = 0.063) and hypertension (47.75 vs 34.41 pmol/l; median, p = 0.056) compared to non-smokers and patients with no history of hypertension. The gene discussed is SOST; the disease is Hypertension.